Compound Detail
CHEMBL5647340
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Basic Information
| ChEMBL ID | CHEMBL5647340 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQPBIVYJDGIVPF-OAHLLOKOSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
434.6
MW (Da)
5.27
ALogP
7
HBA
2
HBD
68.3
PSA (Ų)
0.39
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Son of sevenless homolog 1 CHEMBL2079846 | IC50 | 7.68 | 7.68 | 21.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Son of sevenless homolog 1 | IC50 | = | 21.0 | nM | 7.68 | Inhibition of SOS1 (unknown origin) by HTRF assay | 37778239 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37778239 | 10.1016/j.ejmech.2023.115828 | Son of sevenless homolog 1 | 1 |
Data from ChEMBL 36 via Core Engine