Assay Detail
Functional
CHEMBL5638534
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Antiinflammatory activity against mouse RAW264.7 cells stably transfected with luciferase reporter gene assessed as inhibition of LPS-induced NF-kB activation preincubated for 30 min followed by LPS stimulation for 8 hrs by luciferase based assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Peniditerpenoids A and B: Oxidized Indole Diterpenoids with Osteoclast Differentiation Inhibitory Activity from a Mangrove-Sediment-Derived <i>Penicillium</i> sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.13 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL403183 | — | — | 1 | 5.30 |
| CHEMBL5646817 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL403183 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5646817 | — | IC50 | = | 11000.0 | nM | 4.96 |