Assay Detail
Binding
CHEMBL5638751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CSF1R (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Macrophage colony-stimulating factor 1 receptor (CHEMBL1844) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Selective Imidazopyridine CSF1R Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.27 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4227505 | SOTULETINIB | 2.0 | 1 | 9.00 |
| CHEMBL5095202 | VIMSELTINIB | 3.0 | 1 | 8.70 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4227505 | SOTULETINIB | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5095202 | VIMSELTINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 78.0 | nM | 7.11 |