Assay Detail

CHEMBL5638752

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Binding

Inhibition of c-Kit (unknown origin)

ChEMBL ↗

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Target

Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗

Open DB target context

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Mast/stem cell growth factor receptor Kit (CHEMBL1936) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Mast/stem cell growth factor receptor Kit

CHEMBL1936

Anchored from Assay target.

Protein identity Mast/stem cell growth factor receptor Kit

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Identification of Selective Imidazopyridine CSF1R Inhibitors.

Kane JL, Asmussen G, Batchelor J, Cromwell M, Fezoui M, Fitzgerald M, Giese B, Gladysheva T, Holley S, Keefe K, Kothe M, Lam B, Lim S, Liu J, Ma L, Metz M, Scholte AA, Shum P, Wei L, Woodworth L, Edling A.
ACS Med Chem Lett (2024) 15 : 722 -730
PubMed 38746878 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	5.91	6.32

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL5095202	VIMSELTINIB	3.0	1	6.32
CHEMBL4227505	SOTULETINIB	2.0	1	5.50

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL5095202	VIMSELTINIB	IC50	=	480.0	nM	6.32
CHEMBL4227505	SOTULETINIB	IC50	=	3200.0	nM	5.50