Assay Detail
Binding
CHEMBL5638884
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Inhibition of human MPO using H2O2 as substrate measured after 15 mins by chemiluminescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Myeloperoxidase Inhibitors for Treating Multiple Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.69 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5639106 | — | — | 1 | 9.00 |
| CHEMBL5641842 | — | — | 1 | 8.70 |
| CHEMBL5646914 | — | — | 1 | 8.70 |
| CHEMBL5646667 | — | — | 1 | 8.70 |
| CHEMBL5641725 | — | — | 1 | 8.52 |
| CHEMBL5640015 | — | — | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5639106 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5641842 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5646914 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5646667 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5641725 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5640015 | — | IC50 | = | 3.0 | nM | 8.52 |