Assay Detail
Binding
CHEMBL5647853
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR E746_A750del mutant expressing in human HCC827 cells assessed as cell survival by MTS assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.46 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 9.70 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 9.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 0.6 | nM | 9.22 |