Assay Detail
Functional
CHEMBL5648231
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Antiproliferative activity against human DLD-1 cells assessed as reduction in cell viability incubated for 5 days
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Molecular basis underlying resistance to Mps1/TTK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.11 | 7.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4757879 | — | — | 1 | 7.61 |
| CHEMBL2047943 | — | — | 1 | 7.12 |
| CHEMBL188343 | REVERSINE | — | 1 | 6.92 |
| CHEMBL1236095 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4757879 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL2047943 | — | IC50 | = | 75.4 | nM | 7.12 |
| CHEMBL188343 | REVERSINE | IC50 | = | 120.3 | nM | 6.92 |
| CHEMBL1236095 | — | IC50 | = | 164.8 | nM | 6.78 |