Assay Detail
Functional
CHEMBL5648258
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Inhibition of colony formation in human DLD-1 cells harboring Mps1 S611R mutant assessed as cell survival incubated for 5 days by crystal violet staining based colony formation assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Molecular basis underlying resistance to Mps1/TTK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.90 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4757879 | — | — | 1 | 6.60 |
| CHEMBL1236095 | — | — | 1 | 5.99 |
| CHEMBL4474534 | — | — | 1 | 5.10 |
| CHEMBL188343 | REVERSINE | — | 1 | - |
| CHEMBL2047943 | — | — | 1 | - |
| CHEMBL2140523 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4757879 | — | IC50 | = | 248.8 | nM | 6.60 |
| CHEMBL1236095 | — | IC50 | = | 1017.0 | nM | 5.99 |
| CHEMBL4474534 | — | IC50 | = | 7931.0 | nM | 5.10 |
| CHEMBL188343 | REVERSINE | IC50 | > | 2000.0 | nM | - |
| CHEMBL2047943 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL2140523 | — | IC50 | > | 5000.0 | nM | - |