Assay Detail
Functional
CHEMBL5648303
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of colony formation in human HCT-116 cells harboring Mps1 I531M mutant assessed as cell survival incubated for 5 days by crystal violet staining based colony formation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Molecular basis underlying resistance to Mps1/TTK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.81 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188343 | REVERSINE | — | 1 | 6.28 |
| CHEMBL2047943 | — | — | 1 | 5.97 |
| CHEMBL1236095 | — | — | 1 | 5.79 |
| CHEMBL2140523 | — | — | 1 | 5.51 |
| CHEMBL4474534 | — | — | 1 | 5.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188343 | REVERSINE | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL2047943 | — | IC50 | = | 1079.0 | nM | 5.97 |
| CHEMBL1236095 | — | IC50 | = | 1625.0 | nM | 5.79 |
| CHEMBL2140523 | — | IC50 | = | 3063.0 | nM | 5.51 |
| CHEMBL4474534 | — | IC50 | = | 3234.0 | nM | 5.49 |