Assay Detail
Functional
CHEMBL5653643
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Antagonist activity at ETA receptor (unknown origin) assessed as inhibition of arachidonic acid release by cell based assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.70 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9194 | ATRASENTAN | 3.0 | 1 | 9.70 |
| CHEMBL111277 | — | — | 1 | - |
| CHEMBL332794 | A-192621 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9194 | ATRASENTAN | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL111277 | — | IC50 | - | — | - | |
| CHEMBL332794 | A-192621 | IC50 | - | — | - |