Assay Detail
Binding
CHEMBL5653989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK9/Cyclin T (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T-cell |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.61 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 8.40 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 8.22 |
| CHEMBL14762 | SELICICLIB | 2.0 | 1 | 6.22 |
| CHEMBL445813 | AT-7519 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296468 | BMS-387032 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL445813 | AT-7519 | IC50 | < | 100.0 | nM | - |