Assay Detail
Binding
CHEMBL5654461
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat PDE10A2 assessed as inhibition of cAMP hydrolysis by fluorescence polarization assay
2
Total Activities
1
Compounds Tested
2
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | AD293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (CHEMBL6140) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 8.89 | 8.89 |
| Inhibition | 1 | - | - |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0005090 |
| EFO_TERM | EFO_TERM | - | — | schizophrenia |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2204538 | THPP-1 | — | 2 | 8.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2204538 | THPP-1 | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL2204538 | THPP-1 | Inhibition | - | % | - |