Assay Detail
Binding
CHEMBL5658249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK3 (unknown origin) in presence of ATP by radiometric assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 8.69 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4564280 | — | — | 1 | 9.90 |
| CHEMBL5188882 | — | — | 1 | 9.81 |
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 9.54 |
| CHEMBL2325895 | — | — | 1 | 9.52 |
| CHEMBL5661829 | — | — | 1 | 9.05 |
| CHEMBL1650951 | — | — | 1 | 8.82 |
| CHEMBL5661904 | — | — | 1 | 8.52 |
| CHEMBL3601223 | — | — | 1 | 8.32 |
| CHEMBL5661931 | — | — | 1 | 8.15 |
| CHEMBL5661858 | — | — | 1 | 7.70 |
| CHEMBL4128410 | — | — | 1 | 7.66 |
| CHEMBL4204801 | — | — | 1 | 7.31 |
| CHEMBL3601115 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4564280 | — | IC50 | = | 0.127 | nM | 9.90 |
| CHEMBL5188882 | — | IC50 | = | 0.154 | nM | 9.81 |
| CHEMBL221959 | TOFACITINIB | IC50 | = | 0.292 | nM | 9.54 |
| CHEMBL2325895 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5661829 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1650951 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5661904 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3601223 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL5661931 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5661858 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4128410 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4204801 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL3601115 | — | IC50 | < | 0.5 | nM | - |