Assay Detail
Functional
CHEMBL5659178
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of DNA double strand breaks in human NCI-H358 cells assessed as increase in gamma-H2AX expression at 0.005 to 12 micromol/L incubated for 72 hrs by high content analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H358 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Class of Potent and Cellularly Active Inhibitors Devalidates MTH1 as Broad-Spectrum Cancer Target.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 1 | 5.51 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3782004 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3782004 | — | EC50 | = | 3110.0 | nM | 5.51 |