Assay Detail

CHEMBL5675686

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Functional

Antiproliferative activity against human HT-1080 cells after 2 days by Cell-Titer-Glo assay

ChEMBL ↗

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Target

HT-1080 (CHEMBL614580) ↗

Open DB target context

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HT-1080 (CHEMBL614580) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target HT-1080

CHEMBL614580

Anchored from Assay target.

Protein identity HT-1080

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	HT-1080
Confidence	1 — Organism
Curated By	Autocuration

Target

HT-1080 (CHEMBL614580) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia.

Pappano WN, Guo J, He Y, Ferguson D, Jagadeeswaran S, Osterling DJ, Gao W, Spence JK, Pliushchev M, Sweis RF, Buchanan FG, Michaelides MR, Shoemaker AR, Tse C, Chiang GG.
PLoS One (2015) 10 : 131716 -131716
PubMed 26147105 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	1	8.92	8.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1231795	—	—	1	8.92

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1231795	—	EC50	=	1.2	nM	8.92