Assay Detail
Binding
CHEMBL5676672
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activation of PKC in human U1 cells infected with latent HIV-1 assessed as reversal of HIV-1 latency by measuring increase in p24 antigen level incubated for 48 hrs by chemiluminescent enzyme immunoassay
7
Total Activities
6
Compounds Tested
2
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U1 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Benzolactam-related compounds promote apoptosis of HIV-infected human cells via protein kinase C-induced HIV latency reversal.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.08 | 7.47 |
| Activity | 1 | - | - |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0000764 |
| EFO_TERM | EFO_TERM | - | — | hiv infection |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34971 | — | — | 2 | 7.47 |
| CHEMBL170518 | PROSTRATIN | — | 1 | 6.55 |
| CHEMBL27266 | INDOLACTUM | — | 1 | 6.44 |
| CHEMBL5678793 | — | — | 1 | 5.63 |
| CHEMBL5678789 | — | — | 1 | 5.40 |
| CHEMBL35696 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34971 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL170518 | PROSTRATIN | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL27266 | INDOLACTUM | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5678793 | — | EC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL5678789 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL35696 | — | EC50 | = | 9890.0 | nM | 5.00 |
| CHEMBL34971 | — | Activity | - | — | - |