Compound Detail
CHEMBL35696
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Basic Information
| ChEMBL ID | CHEMBL35696 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TXTPQHMKEMQYBG-JXFKEZNVSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
372.6
MW (Da)
3.53
ALogP
3
HBA
2
HBD
52.6
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.54
Ki 1 meas. best 5.29
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C (PKC) CHEMBL2093867 | EC50 | 5.54 | 5.27 | 2910.0 | 2 |
| Protein kinase C delta type CHEMBL2996 | Ki | 5.29 | 5.29 | 5100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C (PKC) | EC50 | = | 2910.0 | nM | 5.54 | Activation of PKC in human ACH-2 cells infected with latent HIV-1 assessed as re... | 30413535 |
| Protein kinase C delta type | Ki | = | 5100.0 | nM | 5.29 | Displacement of [3H]PDBu from recombinant Protein kinase C delta | 9554881 |
| Protein kinase C (PKC) | EC50 | = | 9890.0 | nM | 5.0 | Activation of PKC in human U1 cells infected with latent HIV-1 assessed as rever... | 30413535 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30413535 | 10.1074/jbc.ra118.005798 | Protein kinase C (PKC) | 4 |
| 30413535 | 10.1074/jbc.ra118.005798 | ADMET | 3 |
| 9554881 | 10.1021/jm970704s | Protein kinase C delta type | 1 |
| 30413535 | 10.1074/jbc.ra118.005798 | ACH-2 cell line | 1 |
| 30413535 | 10.1074/jbc.ra118.005798 | U1 | 1 |
Data from ChEMBL 36 via Core Engine