Assay Detail
Binding
CHEMBL766602
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Displacement of [3H]PDBu from recombinant Protein kinase C delta
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cdelta by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.31 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417692 | — | — | 1 | 9.49 |
| CHEMBL37271 | — | — | 1 | 8.52 |
| CHEMBL34971 | — | — | 1 | 8.23 |
| CHEMBL289892 | — | — | 1 | 7.85 |
| CHEMBL34725 | — | — | 1 | 7.72 |
| CHEMBL28205 | — | — | 1 | 7.50 |
| CHEMBL37684 | — | — | 1 | 7.19 |
| CHEMBL27266 | INDOLACTUM | — | 1 | 7.10 |
| CHEMBL36821 | — | — | 1 | 5.77 |
| CHEMBL267144 | — | — | 1 | 5.77 |
| CHEMBL35696 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417692 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL37271 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL34971 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL289892 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL34725 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL28205 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL37684 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL27266 | INDOLACTUM | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL36821 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL267144 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL35696 | — | Ki | = | 5100.0 | nM | 5.29 |