Compound Detail
CHEMBL37271
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL37271 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UZOFJSPXOMWUFZ-ZQRQZVKFSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
360.5
MW (Da)
4.06
ALogP
3
HBA
2
HBD
52.6
PSA (Ų)
0.62
QED
0
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.7
Ki 1 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C delta type CHEMBL2996 | Ki | 8.52 | 8.52 | 3.0 | 1 |
| HL-60 CHEMBL383 | EC50 | 6.7 | 6.7 | 200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C delta type | Ki | = | 3.0 | nM | 8.52 | Displacement of [3H]PDBu from recombinant Protein kinase C delta | 9554881 |
| HL-60 | EC50 | = | 200.0 | nM | 6.7 | Effective concentration against HL-60 cell differentiation | 9554881 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9554881 | 10.1021/jm970704s | Protein kinase C delta type | 1 |
| 9554881 | 10.1021/jm970704s | HL-60 | 1 |
Data from ChEMBL 36 via Core Engine