Assay Detail
Functional
CHEMBL695265
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Effective concentration against HL-60 cell differentiation
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cdelta by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.68 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289892 | — | — | 1 | 7.70 |
| CHEMBL34725 | — | — | 1 | 7.16 |
| CHEMBL37271 | — | — | 1 | 6.70 |
| CHEMBL36821 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289892 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL34725 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL37271 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL36821 | — | EC50 | = | 7000.0 | nM | 5.16 |