Assay Detail
Binding
CHEMBL5679221
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of intracellular domain of GST-tagged IGF1R (957 to 1367 residues) (unknown origin) expressed in baculovirus expression system using biotin-aminohexyl-AEEEEYMMMMAKKKK-NH2 as substrate pre incubated for 6 hrs followed by substrate addition and measured after 2 hrs in presence of [gamma-33P]-ATP by liquid scintillation counting method
1
Total Activities
1
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Antitumor activity of GSK1904529A, a small-molecule inhibitor of the insulin-like growth factor-I receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 8.80 | 8.80 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0004992 |
| EFO_TERM | EFO_TERM | - | — | cancer |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL466397 | — | — | 1 | 8.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL466397 | — | Ki | = | 1.6 | nM | 8.80 |