Assay Detail
Binding
CHEMBL5680391
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IGF-1R phosphorylation in human Rh41 cells at 0.1 to 1000 nmol/L incubated for 1 hr by Western blotting analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Rh41 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
BMS-754807, a small molecule inhibitor of insulin-like growth factor-1R/IR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.22 | 8.22 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0003869 |
| EFO_TERM | EFO_TERM | - | — | breast neoplasm |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575448 | BMS-754807 | IC50 | = | 6.0 | nM | 8.22 |