Assay Detail

CHEMBL5701404

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Binding affinity against PPIG (unknown origin) assessed as apparent dissociation constant incubated for 1 hr by colloidal coomassie staining based LC-MS/MS analysis

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Peptidyl-prolyl cis-trans isomerase G (CHEMBL3707467) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Peptidyl-prolyl cis-trans isomerase G (CHEMBL3707467) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Peptidyl-prolyl cis-trans isomerase G

CHEMBL3707467

Anchored from Assay target.

Protein identity Peptidyl-prolyl cis-trans isomerase G

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Peptidyl-prolyl cis-trans isomerase G (CHEMBL3707467) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.

Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T.
Nature (2011) 478 : 529 -533
PubMed 21964340 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	7.96	7.96

Assay Parameters

Parameter	Type	Value	Units	Text
EFO_ID	EFO_ID	-	—	EFO:0000565
EFO_TERM	EFO_TERM	-	—	leukemia

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1232461	MOLIBRESIB	2.0	1	7.96

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1232461	MOLIBRESIB	Kd	=	11.0	nM	7.96