Assay Detail
Functional
CHEMBL5707355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harboring EGFR L858R mutant assessed as inhibition of cell growth incubated for 72 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel mutant-selective EGFR kinase inhibitors against EGFR T790M.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.51 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643976 | — | — | 1 | 8.70 |
| CHEMBL1229592 | — | — | 1 | 8.70 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 8.52 |
| CHEMBL180022 | NERATINIB | 4.0 | 1 | 8.52 |
| CHEMBL91867 | — | — | 1 | 8.40 |
| CHEMBL1643989 | — | — | 1 | 8.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643976 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1229592 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL180022 | NERATINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL91867 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1643989 | — | IC50 | = | 6.0 | nM | 8.22 |