Assay Detail
Functional
CHEMBL5711668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human PC-9 cells harboring del19 mutant assessed as inhibition of cell viability incubated for 72 hrs by CellTiter-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-9 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.66 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 9.20 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 8.13 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.79 |
| CHEMBL3397300 | — | — | 1 | 7.34 |
| CHEMBL3545311 | BRIGATINIB | 4.0 | 1 | 6.88 |
| CHEMBL4203266 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1173655 | AFATINIB | IC50 | = | 0.638 | nM | 9.20 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 7.463 | nM | 8.13 |
| CHEMBL939 | GEFITINIB | IC50 | = | 16.38 | nM | 7.79 |
| CHEMBL3397300 | — | IC50 | = | 46.18 | nM | 7.34 |
| CHEMBL3545311 | BRIGATINIB | IC50 | = | 132.8 | nM | 6.88 |
| CHEMBL4203266 | — | IC50 | = | 253.0 | nM | 6.60 |