Assay Detail
Binding
CHEMBL5711898
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of JAK1/JAK2 in human HEKa cells assessed as reduction in IL-31-induced STAT3 phosphorylation by flow cytometry analysis
1
Total Activities
1
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEKa |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.52 | 8.52 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | HP:0001370 |
| EFO_TERM | EFO_TERM | - | — | rheumatoid arthritis |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3622821 | UPADACITINIB | 4.0 | 1 | 8.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3622821 | UPADACITINIB | IC50 | = | 3.0 | nM | 8.52 |