Assay Detail
Functional
CHEMBL5712035
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Antiproliferative activity against human BT-474 cells assessed as reduction in cell viability incubated for 5 days by celltiter-glo assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BT-474 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 5.88 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5712048 | — | — | 1 | 6.96 |
| CHEMBL5712063 | — | — | 1 | 6.59 |
| CHEMBL4795065 | Borussertib | — | 1 | 6.43 |
| CHEMBL5712042 | — | — | 1 | 6.33 |
| CHEMBL5712046 | — | — | 1 | 6.21 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.21 |
| CHEMBL5712066 | — | — | 1 | 5.96 |
| CHEMBL2325741 | CAPIVASERTIB | 4.0 | 1 | 5.79 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 5.77 |
| CHEMBL5712049 | — | — | 1 | 5.75 |
| CHEMBL5712044 | — | — | 1 | 5.71 |
| CHEMBL5712045 | — | — | 1 | 5.64 |
| CHEMBL2177390 | IPATASERTIB | 3.0 | 1 | 5.62 |
| CHEMBL5712059 | — | — | 1 | 5.40 |
| CHEMBL5712058 | — | — | 1 | 5.34 |
| CHEMBL5712055 | — | — | 1 | 5.28 |
| CHEMBL5712061 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5712048 | — | EC50 | = | 109.0 | nM | 6.96 |
| CHEMBL5712063 | — | EC50 | = | 259.0 | nM | 6.59 |
| CHEMBL4795065 | Borussertib | EC50 | = | 373.0 | nM | 6.43 |
| CHEMBL5712042 | — | EC50 | = | 464.0 | nM | 6.33 |
| CHEMBL5712046 | — | EC50 | = | 621.0 | nM | 6.21 |
| CHEMBL53463 | DOXORUBICIN | EC50 | = | 623.0 | nM | 6.21 |
| CHEMBL5712066 | — | EC50 | = | 1104.0 | nM | 5.96 |
| CHEMBL2325741 | CAPIVASERTIB | EC50 | = | 1605.0 | nM | 5.79 |
| CHEMBL1079175 | MK-2206 | EC50 | = | 1682.0 | nM | 5.77 |
| CHEMBL5712049 | — | EC50 | = | 1785.0 | nM | 5.75 |
| CHEMBL5712044 | — | EC50 | = | 1956.0 | nM | 5.71 |
| CHEMBL5712045 | — | EC50 | = | 2268.0 | nM | 5.64 |
| CHEMBL2177390 | IPATASERTIB | EC50 | = | 2371.0 | nM | 5.62 |
| CHEMBL5712059 | — | EC50 | = | 4019.0 | nM | 5.40 |
| CHEMBL5712058 | — | EC50 | = | 4617.0 | nM | 5.34 |
| CHEMBL5712055 | — | EC50 | = | 5211.0 | nM | 5.28 |
| CHEMBL5712061 | — | EC50 | = | 11971.0 | nM | 4.92 |