Assay Detail
Binding
CHEMBL5714435
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GLUT1 in human OVCAR-3 cells assessed as decrease in conversion of D-[5-3H(N)]-glucose to 3H2O incubated for 24 hrs by liquid scintillation counting
2
Total Activities
1
Compounds Tested
2
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | OVCAR-3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 2, facilitated glucose transporter member 1 (CHEMBL2535) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.60 | 7.60 |
| Inhibition | 1 | - | - |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0008170 |
| EFO_ID | EFO_ID | - | — | MONDO:0008170 |
| EFO_TERM | EFO_TERM | - | — | ovarian cancer |
| EFO_TERM | EFO_TERM | - | — | ovarian cancer |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448899 | BAY-876 | — | 2 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448899 | BAY-876 | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4448899 | BAY-876 | Inhibition | - | % | - |