Assay Detail
Binding
CHEMBL5716355
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human aurora B
4
Total Activities
4
Compounds Tested
2
Activity Types
4
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aurora kinase inhibitors: a new class of targeted drugs in cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.46 | 7.46 |
| Ki | 2 | 8.60 | 9.45 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0003060 |
| EFO_ID | EFO_ID | - | — | EFO:0000588 |
| EFO_TERM | EFO_TERM | - | — | non-small cell lung carcinoma |
| EFO_TERM | EFO_TERM | - | — | mesothelioma |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415049 | BARASERTIB | 3.0 | 1 | 9.45 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 7.75 |
| CHEMBL363160 | PHA-680632 | — | 1 | 7.46 |
| CHEMBL495727 | AT-9283 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415049 | BARASERTIB | Ki | = | 0.359 | nM | 9.45 |
| CHEMBL572878 | TOZASERTIB | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL363160 | PHA-680632 | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL495727 | AT-9283 | IC50 | < | 3.0 | nM | - |