Assay Detail
Binding
CHEMBL5716419
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Aurora B in human SW620 cells assessed as inhibition of histone H3 phosphorylation at Ser10 residue incubated for 48 hrs
1
Total Activities
1
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SW620 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.99 | 7.99 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0004992 |
| EFO_TERM | EFO_TERM | - | — | cancer |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL415049 | BARASERTIB | 3.0 | 1 | 7.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL415049 | BARASERTIB | IC50 | = | 10.27 | nM | 7.99 |