Assay Detail
Functional
CHEMBL5716553
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Vasorelaxant activity in isolated Chinchilla rabbit saphenous artery vessels assessed as inhibition of phenylephrine-mediated contraction
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Saphenous artery |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.48 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5270382 | — | — | 1 | 7.70 |
| CHEMBL5722966 | — | — | 1 | 7.25 |
| CHEMBL1971943 | BAY-549 | — | 1 | 7.19 |
| CHEMBL5722984 | — | — | 1 | 7.09 |
| CHEMBL5723002 | — | — | 1 | 7.08 |
| CHEMBL5723015 | — | — | 1 | 7.05 |
| CHEMBL5428272 | — | — | 1 | 7.00 |
| CHEMBL5722939 | — | — | 1 | 6.64 |
| CHEMBL5274003 | — | — | 1 | 6.57 |
| CHEMBL5722956 | — | — | 1 | 6.43 |
| CHEMBL5722977 | — | — | 1 | 6.39 |
| CHEMBL5722955 | — | — | 1 | 6.34 |
| CHEMBL5722947 | — | — | 1 | 6.30 |
| CHEMBL5723011 | — | — | 1 | 6.24 |
| CHEMBL5722999 | — | — | 1 | 6.15 |
| CHEMBL5723017 | — | — | 1 | 6.03 |
| CHEMBL5722951 | — | — | 1 | 5.96 |
| CHEMBL5722974 | — | — | 1 | 5.92 |
| CHEMBL5722952 | — | — | 1 | 5.82 |
| CHEMBL5722953 | — | — | 1 | 5.77 |
| CHEMBL5723027 | — | — | 1 | 5.17 |
| CHEMBL5722997 | — | — | 1 | - |
| CHEMBL5722964 | — | — | 1 | - |
| CHEMBL5722995 | — | — | 1 | - |
| CHEMBL5723010 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5270382 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5722966 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1971943 | BAY-549 | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL5722984 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5723002 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL5723015 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL5428272 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5722939 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5274003 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5722956 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5722977 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5722955 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5722947 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5723011 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5722999 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5723017 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5722951 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5722974 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5722952 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5722953 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5723027 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL5722997 | — | IC50 | - | — | - | |
| CHEMBL5722964 | — | IC50 | - | — | - | |
| CHEMBL5722995 | — | IC50 | - | — | - | |
| CHEMBL5723010 | — | IC50 | - | — | - |