Assay Detail
Binding
CHEMBL5717702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CDK9/Cyclin T1 (unknown origin) using ULight MBP peptide as substrate in presence of ATP incubated for 1 hr by FRET based LANCE Ultra KinaSelect screen assay
4
Total Activities
4
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.59 | 9.00 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0000095 |
| EFO_TERM | EFO_TERM | - | — | chronic lymphocytic leukemia |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 9.00 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 8.30 |
| CHEMBL5722954 | — | — | 1 | 7.36 |
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296468 | BMS-387032 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5722954 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | IC50 | = | 1942.0 | nM | 5.71 |