Assay Detail
Binding
CHEMBL5719621
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IGF1R in human U-266 cells assessed as reduction of cell growth incubated for 72 hrs by CellTiter 96 aqueous one solution cell proliferation assay
3
Total Activities
3
Compounds Tested
1
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | U-266 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL1957) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule inhibitor screen identifies synergistic activity of the bromodomain inhibitor CPI203 and bortezomib in drug resistant myeloma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.13 | 5.37 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | EFO:0001378 |
| EFO_TERM | EFO_TERM | - | — | multiple myeloma |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399021 | — | — | 1 | 5.37 |
| CHEMBL464552 | — | — | 1 | 5.01 |
| CHEMBL466397 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399021 | — | IC50 | = | 4240.6 | nM | 5.37 |
| CHEMBL464552 | — | IC50 | = | 9773.4 | nM | 5.01 |
| CHEMBL466397 | — | IC50 | = | 10000.0 | nM | 5.00 |