Assay Detail
Binding
CHEMBL5720041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PRMT8 using (3H) methylated biotin labelled peptide as substrate in presence of 3H-SAM by scintillation proximity assay
6
Total Activities
6
Compounds Tested
2
Activity Types
2
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 8 (CHEMBL3108648) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.07 | 8.30 |
| Inhibition | 3 | - | - |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| EFO_ID | EFO_ID | - | — | MONDO:0004992 |
| EFO_TERM | EFO_TERM | - | — | cancer |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3901808 | — | — | 1 | 8.30 |
| CHEMBL5722978 | — | — | 1 | 7.38 |
| CHEMBL5722993 | — | — | 1 | 5.52 |
| CHEMBL5094386 | — | — | 1 | - |
| CHEMBL5722936 | — | — | 1 | - |
| CHEMBL5723025 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3901808 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5722978 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL5722993 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5094386 | — | Inhibition | - | % | - | |
| CHEMBL5722936 | — | Inhibition | - | % | - | |
| CHEMBL5723025 | — | Inhibition | - | % | - |