Assay Detail
Binding
CHEMBL5720979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PI3Kbeta assessed as reduction in PIP3 product complex formation
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of Human Class I vs Class III Phosphatidylinositol 3'-Kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.43 | 7.20 |
| Ki | 1 | 9.89 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | 2.0 | 1 | 9.89 |
| CHEMBL3218578 | BGT-226 FREE BASE | 2.0 | 1 | 7.20 |
| CHEMBL1765602 | — | — | 1 | 6.75 |
| CHEMBL5723005 | — | — | 1 | 6.70 |
| CHEMBL1229535 | — | — | 1 | 6.23 |
| CHEMBL3545097 | SAPANISERTIB | 2.0 | 1 | 5.28 |
| CHEMBL3622372 | — | — | 1 | - |
| CHEMBL3781415 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1236962 | OMIPALISIB | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL3218578 | BGT-226 FREE BASE | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1765602 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5723005 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1229535 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3545097 | SAPANISERTIB | EC50 | = | 5290.0 | nM | 5.28 |
| CHEMBL3622372 | — | EC50 | > | 10.0 | nM | - |
| CHEMBL3781415 | — | EC50 | > | 9100.0 | nM | - |