Assay Detail
Binding
CHEMBL5720980
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human VPS34 assessed as reduction in PIP3 product complex formation measured after 30 mins in presence of ATP by quantitative PI3P ELISA assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 3-kinase catalytic subunit type 3 (CHEMBL1075165) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of Human Class I vs Class III Phosphatidylinositol 3'-Kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.19 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3622372 | — | — | 1 | 8.96 |
| CHEMBL3218578 | BGT-226 FREE BASE | 2.0 | 1 | 8.15 |
| CHEMBL3781415 | — | — | 1 | 8.03 |
| CHEMBL1765602 | — | — | 1 | 7.94 |
| CHEMBL1229535 | — | — | 1 | 6.66 |
| CHEMBL1236962 | OMIPALISIB | 2.0 | 1 | 6.44 |
| CHEMBL5723005 | — | — | 1 | 6.11 |
| CHEMBL3545097 | SAPANISERTIB | 2.0 | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3622372 | — | EC50 | = | 1.11 | nM | 8.96 |
| CHEMBL3218578 | BGT-226 FREE BASE | EC50 | = | 7.03 | nM | 8.15 |
| CHEMBL3781415 | — | EC50 | = | 9.4 | nM | 8.03 |
| CHEMBL1765602 | — | EC50 | = | 11.5 | nM | 7.94 |
| CHEMBL1229535 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1236962 | OMIPALISIB | EC50 | = | 364.0 | nM | 6.44 |
| CHEMBL5723005 | — | EC50 | = | 784.0 | nM | 6.11 |
| CHEMBL3545097 | SAPANISERTIB | EC50 | = | 5620.0 | nM | 5.25 |