Assay Detail

CHEMBL5721269

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Binding

Inhibition of 5HT receptor (unknown origin)

ChEMBL ↗

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Target

Serotonin (5-HT) receptor (CHEMBL2096904) ↗

Open DB target context

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Serotonin (5-HT) receptor (CHEMBL2096904) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Serotonin (5-HT) receptor

CHEMBL2096904

Anchored from Assay target.

Protein identity Serotonin (5-HT) receptor

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Serotonin (5-HT) receptor (CHEMBL2096904) ↗

Type	PROTEIN FAMILY
Organism	Homo sapiens

Publication

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.

Meier JC, Tallant C, Fedorov O, Witwicka H, Hwang SY, van Stiphout RG, Lambert JP, Rogers C, Yapp C, Gerstenberger BS, Fedele V, Savitsky P, Heidenreich D, Daniels DL, Owen DR, Fish PV, Igoe NM, Bayle ED, Haendler B, Oppermann UCT, Buffa F, Brennan PE, Müller S, Gingras AC, Odgren PR, Birnbaum MJ, Knapp S.
ACS Chem Biol (2017) 12 : 2619 -2630
PubMed 28849908 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.96	8.96

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL11	IMIPRAMINE	4.0	1	8.96

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL11	IMIPRAMINE	IC50	=	1.1	nM	8.96