Assay Detail
Binding
CHEMBL5730502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Glycocholic acid Uptake Radiometric Assay: ISBT Hu HEK Uptake SPA 13203 IBAT HUM Ileal Bile Acid Transporter Human HEK Glycocholic acid Uptake Radiometric¿SPA Inhibitor IC50 Mean IC50 (nM) was determined.
36
Total Activities
12
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
IBAT inhibitors for the treatment of liver disease
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 9.58 | 9.96 |
| kon | 12 | - | - |
| k_off | 12 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5778792 | — | — | 3 | 9.96 |
| CHEMBL5980362 | — | — | 3 | 9.89 |
| CHEMBL5890939 | — | — | 3 | 9.82 |
| CHEMBL4297588 | ODEVIXIBAT | 4.0 | 3 | 9.80 |
| CHEMBL5868054 | — | — | 3 | 9.74 |
| CHEMBL5776872 | — | — | 3 | 9.70 |
| CHEMBL5808613 | — | — | 3 | 9.52 |
| CHEMBL6016158 | — | — | 3 | 9.46 |
| CHEMBL6045294 | — | — | 3 | 9.44 |
| CHEMBL6002118 | — | — | 3 | 9.41 |
| CHEMBL5906168 | — | — | 3 | 9.35 |
| CHEMBL3039515 | ELOBIXIBAT | 3.0 | 3 | 8.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5778792 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL5980362 | — | IC50 | = | 0.13 | nM | 9.89 |
| CHEMBL5890939 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL4297588 | ODEVIXIBAT | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL5868054 | — | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL5776872 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL5808613 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL6016158 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL6045294 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL6002118 | — | IC50 | = | 0.39 | nM | 9.41 |
| CHEMBL5906168 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL3039515 | ELOBIXIBAT | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL6045294 | — | k_off | = | - | s-1 | - |
| CHEMBL6045294 | — | kon | = | - | — | - |
| CHEMBL4297588 | ODEVIXIBAT | k_off | = | - | s-1 | - |
| CHEMBL4297588 | ODEVIXIBAT | kon | = | - | — | - |
| CHEMBL6016158 | — | k_off | = | - | s-1 | - |
| CHEMBL6016158 | — | kon | = | - | — | - |
| CHEMBL5868054 | — | k_off | = | - | s-1 | - |
| CHEMBL5868054 | — | kon | = | - | — | - |
| CHEMBL6002118 | — | k_off | = | - | s-1 | - |
| CHEMBL6002118 | — | kon | = | - | — | - |
| CHEMBL5906168 | — | k_off | = | - | s-1 | - |
| CHEMBL5906168 | — | kon | = | - | — | - |
| CHEMBL5778792 | — | kon | = | - | — | - |
| CHEMBL5778792 | — | k_off | = | - | s-1 | - |
| CHEMBL3039515 | ELOBIXIBAT | k_off | = | - | s-1 | - |
| CHEMBL5776872 | — | kon | = | - | — | - |
| CHEMBL5776872 | — | k_off | = | - | s-1 | - |
| CHEMBL3039515 | ELOBIXIBAT | kon | = | - | — | - |
| CHEMBL5890939 | — | kon | = | - | — | - |
| CHEMBL5980362 | — | k_off | = | - | s-1 | - |
| CHEMBL5890939 | — | k_off | = | - | s-1 | - |
| CHEMBL5980362 | — | kon | = | - | — | - |
| CHEMBL5808613 | — | k_off | = | - | s-1 | - |
| CHEMBL5808613 | — | kon | = | - | — | - |