Assay Detail
Binding
CHEMBL5730769
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Adaptor Kinase Assay of LRRK2 [G2019S]: In vitro kinase assays were conducted at Invitrogen (Madison, Wis.) using the SelectScreen Kinase Profiling Service.
6
Total Activities
2
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Leucine-rich repeat serine/threonine-protein kinase 2 (CHEMBL1075104) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrimido-diazepinone compounds and methods of treating disorders
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.39 | 8.30 |
| kon | 2 | - | - |
| k_off | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381339 | — | — | 3 | 8.30 |
| CHEMBL5687018 | — | — | 3 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381339 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5687018 | — | IC50 | = | 339.0 | nM | 6.47 |
| CHEMBL2381339 | — | kon | = | - | — | - |
| CHEMBL2381339 | — | k_off | = | - | s-1 | - |
| CHEMBL5687018 | — | kon | = | - | — | - |
| CHEMBL5687018 | — | k_off | = | - | s-1 | - |