Assay Detail
Binding
CHEMBL5732883
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition Assay: HDAC inhibition assays can be performed, e.g., in a cell, in a cell extract, or in a cell-free mixture. Exemplary HDAC inhibition assays are described in Pérez-Balado et al., 2007, J. Med. Chem., 50:2497-2505; Herman et al., 2006, Nat. Chem. Biol., 2:551-558; and Beckers et al., 2007, Int. J. Cancer, 121:1138-48.
36
Total Activities
11
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.80 | 6.52 |
| kon | 12 | - | - |
| k_off | 12 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3970532 | — | — | 3 | 6.52 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 3 | 6.23 |
| CHEMBL3940985 | — | — | 6 | 6.16 |
| CHEMBL3958365 | — | — | 3 | 6.10 |
| CHEMBL3953107 | — | — | 3 | 5.85 |
| CHEMBL3944388 | — | — | 3 | 5.80 |
| CHEMBL3921933 | — | — | 3 | 5.75 |
| CHEMBL3920131 | — | — | 3 | 5.64 |
| CHEMBL3916454 | — | — | 3 | 5.44 |
| CHEMBL3934253 | — | — | 3 | 5.14 |
| CHEMBL3930868 | — | — | 3 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3970532 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3940985 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3940985 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3958365 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3953107 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3944388 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL3921933 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3920131 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3916454 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3934253 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3930868 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3958365 | — | k_off | = | - | s-1 | - |
| CHEMBL3958365 | — | kon | = | - | — | - |
| CHEMBL3920131 | — | k_off | = | - | s-1 | - |
| CHEMBL3920131 | — | kon | = | - | — | - |
| CHEMBL3940985 | — | k_off | = | - | s-1 | - |
| CHEMBL3940985 | — | kon | = | - | — | - |
| CHEMBL3970532 | — | k_off | = | - | s-1 | - |
| CHEMBL3970532 | — | kon | = | - | — | - |
| CHEMBL3940985 | — | k_off | = | - | s-1 | - |
| CHEMBL3940985 | — | kon | = | - | — | - |
| CHEMBL27759 | ENTINOSTAT | k_off | = | - | s-1 | - |
| CHEMBL27759 | ENTINOSTAT | kon | = | - | — | - |
| CHEMBL3930868 | — | kon | = | - | — | - |
| CHEMBL3930868 | — | k_off | = | - | s-1 | - |
| CHEMBL3934253 | — | k_off | = | - | s-1 | - |
| CHEMBL3953107 | — | kon | = | - | — | - |
| CHEMBL3953107 | — | k_off | = | - | s-1 | - |
| CHEMBL3921933 | — | kon | = | - | — | - |
| CHEMBL3934253 | — | kon | = | - | — | - |
| CHEMBL3921933 | — | k_off | = | - | s-1 | - |
| CHEMBL3944388 | — | kon | = | - | — | - |
| CHEMBL3944388 | — | k_off | = | - | s-1 | - |
| CHEMBL3916454 | — | kon | = | - | — | - |
| CHEMBL3916454 | — | k_off | = | - | s-1 | - |