Assay Detail
Binding
CHEMBL5733413
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Inhibition Assay: Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instructions with 128 μM ATP and 28 nM Aurora B (Invitrogen cat #PV3970). The % inhibition values were determined according to the manufacturer's directions and IC50 values were obtained using a non-linear 4 point logistic curve fit (XLfit4, IDBS)
588
Total Activities
176
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Kinase inhibitors and method of treating cancer
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 196 | 6.26 | 6.26 |
| kon | 196 | - | - |
| k_off | 196 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6003463 | — | — | 3 | 6.26 |
| CHEMBL5930841 | — | — | 3 | 6.26 |
| CHEMBL5867051 | — | — | 3 | 6.26 |
| CHEMBL6022897 | — | — | 3 | 6.26 |
| CHEMBL5927653 | — | — | 3 | 6.26 |
| CHEMBL6003078 | — | — | 3 | 6.26 |
| CHEMBL6022189 | — | — | 3 | 6.26 |
| CHEMBL3353359 | — | — | 3 | 6.26 |
| CHEMBL6017652 | — | — | 3 | 6.26 |
| CHEMBL5919291 | — | — | 3 | 6.26 |
| CHEMBL4461353 | — | — | 3 | 6.26 |
| CHEMBL5853510 | — | — | 3 | 6.26 |
| CHEMBL5814945 | — | — | 3 | 6.26 |
| CHEMBL6000486 | — | — | 3 | 6.26 |
| CHEMBL5860912 | — | — | 3 | 6.26 |
| CHEMBL5966786 | — | — | 3 | 6.26 |
| CHEMBL6032125 | — | — | 3 | 6.26 |
| CHEMBL5781899 | — | — | 6 | 6.26 |
| CHEMBL6021436 | — | — | 3 | 6.26 |
| CHEMBL5850589 | — | — | 3 | 6.26 |
| CHEMBL5767225 | — | — | 3 | 6.26 |
| CHEMBL5982085 | — | — | 3 | 6.26 |
| CHEMBL5766613 | — | — | 3 | 6.26 |
| CHEMBL5934595 | — | — | 3 | 6.26 |
| CHEMBL3353362 | — | — | 6 | 6.26 |
| CHEMBL5924429 | — | — | 3 | 6.26 |
| CHEMBL5985183 | — | — | 3 | - |
| CHEMBL5844219 | — | — | 3 | - |
| CHEMBL4467348 | — | — | 3 | - |
| CHEMBL4516793 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6000486 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6003463 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5860912 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5966786 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6032125 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5781899 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5919291 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6021436 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6017652 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3353359 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6022189 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5853510 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5814945 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6003078 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5850589 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4461353 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5930841 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL3353362 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5934595 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5766613 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5982085 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5767225 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6022897 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5924429 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5927653 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5867051 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5867051 | — | k_off | = | - | s-1 | - |
| CHEMBL5873841 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5867051 | — | kon | = | - | — | - |
| CHEMBL6003078 | — | k_off | = | - | s-1 | - |
| CHEMBL3353343 | — | kon | = | - | — | - |
| CHEMBL3353343 | — | k_off | = | - | s-1 | - |
| CHEMBL5873841 | — | k_off | = | - | s-1 | - |
| CHEMBL3408949 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL3408949 | — | kon | = | - | — | - |
| CHEMBL3408949 | — | k_off | = | - | s-1 | - |
| CHEMBL6003078 | — | kon | = | - | — | - |
| CHEMBL6022897 | — | kon | = | - | — | - |
| CHEMBL5900316 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5900316 | — | kon | = | - | — | - |
| CHEMBL5900316 | — | k_off | = | - | s-1 | - |
| CHEMBL5893653 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5893653 | — | kon | = | - | — | - |
| CHEMBL5893653 | — | k_off | = | - | s-1 | - |
| CHEMBL6024622 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL6024622 | — | kon | = | - | — | - |
| CHEMBL6024622 | — | k_off | = | - | s-1 | - |
| CHEMBL5746090 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL5746090 | — | k_off | = | - | s-1 | - |
| CHEMBL5746090 | — | kon | = | - | — | - |