Assay Detail
Binding
CHEMBL5733422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition Assay: The in vitro activity of the compounds described herein in inhibiting TAK1, HCK, and other kinases were obtained using an Invitrogen Select Screening assay as known in the art.
24
Total Activities
8
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methods to treat lymphoplasmacytic lymphoma
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.53 | 7.64 |
| kon | 8 | - | - |
| k_off | 8 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5950918 | — | — | 3 | 7.64 |
| CHEMBL5915826 | — | — | 3 | 7.60 |
| CHEMBL5827081 | — | — | 3 | 7.16 |
| CHEMBL5834925 | — | — | 3 | 6.71 |
| CHEMBL6044253 | — | — | 3 | 6.34 |
| CHEMBL6014241 | — | — | 3 | 5.94 |
| CHEMBL5778860 | — | — | 3 | 5.47 |
| CHEMBL5994443 | — | — | 3 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5950918 | — | IC50 | = | 22.9 | nM | 7.64 |
| CHEMBL5915826 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL5827081 | — | IC50 | = | 69.7 | nM | 7.16 |
| CHEMBL5834925 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL6044253 | — | IC50 | = | 459.0 | nM | 6.34 |
| CHEMBL6014241 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL5778860 | — | IC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL5994443 | — | IC50 | = | 3910.0 | nM | 5.41 |
| CHEMBL5950918 | — | kon | = | - | — | - |
| CHEMBL5950918 | — | k_off | = | - | s-1 | - |
| CHEMBL5834925 | — | kon | = | - | — | - |
| CHEMBL5834925 | — | k_off | = | - | s-1 | - |
| CHEMBL6044253 | — | kon | = | - | — | - |
| CHEMBL6044253 | — | k_off | = | - | s-1 | - |
| CHEMBL5994443 | — | kon | = | - | — | - |
| CHEMBL5994443 | — | k_off | = | - | s-1 | - |
| CHEMBL6014241 | — | kon | = | - | — | - |
| CHEMBL6014241 | — | k_off | = | - | s-1 | - |
| CHEMBL5778860 | — | kon | = | - | — | - |
| CHEMBL5778860 | — | k_off | = | - | s-1 | - |
| CHEMBL5827081 | — | kon | = | - | — | - |
| CHEMBL5827081 | — | k_off | = | - | s-1 | - |
| CHEMBL5915826 | — | kon | = | - | — | - |
| CHEMBL5915826 | — | k_off | = | - | s-1 | - |