Assay Detail
Binding
CHEMBL5734576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Radiometric Filter Plate MLK3 Assay: 200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 μCi/assay 33P ATP and appropriate concentrations of compounds. After a twenty minute incubation, the reactions were washed through filter plates and read on a scintillation counter.
612
Total Activities
202
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 11 (CHEMBL2708) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Mixed lineage kinase inhibitors for HIV/AIDS therapies
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 204 | 6.26 | 6.26 |
| kon | 204 | - | - |
| k_off | 204 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6057879 | — | — | 3 | 6.26 |
| CHEMBL5866778 | — | — | 3 | 6.26 |
| CHEMBL5833750 | — | — | 3 | 6.26 |
| CHEMBL5903761 | — | — | 3 | 6.26 |
| CHEMBL5924266 | — | — | 3 | 6.26 |
| CHEMBL5795536 | — | — | 3 | 6.26 |
| CHEMBL5822326 | — | — | 3 | 6.26 |
| CHEMBL5874897 | — | — | 3 | 6.26 |
| CHEMBL5939203 | — | — | 3 | 6.26 |
| CHEMBL6056073 | — | — | 3 | 6.26 |
| CHEMBL5754308 | — | — | 3 | 6.26 |
| CHEMBL5980186 | — | — | 3 | 6.26 |
| CHEMBL5824848 | — | — | 3 | 6.26 |
| CHEMBL6054384 | — | — | 3 | 6.26 |
| CHEMBL6011208 | — | — | 3 | 6.26 |
| CHEMBL2436980 | — | — | 3 | 6.26 |
| CHEMBL5820064 | — | — | 3 | 6.26 |
| CHEMBL6053838 | — | — | 3 | 6.26 |
| CHEMBL5867576 | — | — | 3 | 6.26 |
| CHEMBL5857991 | — | — | 3 | 6.26 |
| CHEMBL5767851 | — | — | 3 | 6.26 |
| CHEMBL6056588 | — | — | 3 | 6.26 |
| CHEMBL5809701 | — | — | 3 | 6.26 |
| CHEMBL6032693 | — | — | 3 | 6.26 |
| CHEMBL5797959 | — | — | 3 | 6.26 |
| CHEMBL6020616 | — | — | 3 | 6.26 |
| CHEMBL5752567 | — | — | 3 | 6.26 |
| CHEMBL5742705 | — | — | 3 | 6.26 |
| CHEMBL6061341 | — | — | 3 | 6.26 |
| CHEMBL5759256 | — | — | 3 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5824848 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6054384 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5985740 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6056073 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5824546 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5907171 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6053010 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5754308 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6034016 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5939203 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5874897 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5854229 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5980186 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5924266 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5793409 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5867576 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5854229 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5969073 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5822326 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5833482 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6053838 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6057879 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5822114 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6011208 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6025490 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5852501 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5968193 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5813460 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5920549 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6032693 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5856572 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5809701 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5906172 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5818653 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5866778 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL6056588 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5964124 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5767851 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5795536 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5822739 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5857991 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5887423 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5817918 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5833750 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5890031 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5903761 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5787061 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4754003 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5837942 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5980455 | — | IC50 | = | 550.0 | nM | 6.26 |