Assay Detail
Binding
CHEMBL5734602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition Activity Assay: Screening Method:Name of method: Activity Evaluation of DPP4, Fluorescence.Instrument: Microplate reader, Envision (PerkinElmer, USA).Material: human DPP4, which was, in this experiment, obtained by using baculovirus expression system in insect cells. Substrate was Gly-Pro-AMC.Process:DPP4 can specifically hydrolyze the substrate, Gly-Pro-AMC to produce a product, AMC, which, excited by UV light at 355 nm, can produce emission light at 460 nm. Linear change of fluorescence values were dynamically measured at 460 nm wavelengths per unit time, thereby calculating DPP4 activity. MERK-0431 was used as a control compound in the experiment.
96
Total Activities
32
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Six-membered ring benzo derivatives as DPP-4 inhibitor and use thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.26 | 8.70 |
| kon | 32 | - | - |
| k_off | 32 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3944427 | — | — | 3 | 8.70 |
| CHEMBL2105762 | OMARIGLIPTIN | 4.0 | 3 | 8.70 |
| CHEMBL4550812 | — | — | 3 | 8.70 |
| CHEMBL5914704 | — | — | 3 | 8.40 |
| CHEMBL3932825 | — | — | 3 | 8.22 |
| CHEMBL5944167 | — | — | 3 | 8.04 |
| CHEMBL5882105 | — | — | 3 | 7.96 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 3 | 7.85 |
| CHEMBL3928073 | — | — | 3 | 7.82 |
| CHEMBL5857197 | — | — | 3 | 7.75 |
| CHEMBL3901191 | — | — | 3 | 7.70 |
| CHEMBL3942843 | — | — | 3 | 7.52 |
| CHEMBL5976169 | — | — | 3 | 7.48 |
| CHEMBL3979508 | — | — | 3 | 7.41 |
| CHEMBL6057630 | — | — | 3 | 7.26 |
| CHEMBL5826806 | — | — | 3 | 7.25 |
| CHEMBL5749167 | — | — | 3 | 7.16 |
| CHEMBL5980526 | — | — | 3 | 7.13 |
| CHEMBL5786497 | — | — | 3 | 7.11 |
| CHEMBL5829004 | — | — | 3 | 6.96 |
| CHEMBL3959577 | — | — | 3 | 6.81 |
| CHEMBL5750623 | — | — | 3 | 6.77 |
| CHEMBL6033078 | — | — | 3 | 6.69 |
| CHEMBL6011250 | — | — | 3 | 6.68 |
| CHEMBL6013719 | — | — | 3 | 6.67 |
| CHEMBL5964811 | — | — | 3 | 6.59 |
| CHEMBL5756206 | — | — | 3 | 6.55 |
| CHEMBL5916381 | — | — | 3 | 6.47 |
| CHEMBL5958101 | — | — | 3 | 6.25 |
| CHEMBL5902002 | — | — | 3 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105762 | OMARIGLIPTIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4550812 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3944427 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5914704 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3932825 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5944167 | — | IC50 | = | 9.17 | nM | 8.04 |
| CHEMBL5882105 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3928073 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL5857197 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3901191 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3942843 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5976169 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3979508 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL6057630 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5826806 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5749167 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5980526 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5786497 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL5829004 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3959577 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL5750623 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL6033078 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL6011250 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL6013719 | — | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL5964811 | — | IC50 | = | 254.0 | nM | 6.59 |
| CHEMBL5756206 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL5916381 | — | IC50 | = | 338.0 | nM | 6.47 |
| CHEMBL5958101 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL5902002 | — | IC50 | = | 678.0 | nM | 6.17 |
| CHEMBL5814595 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL6051249 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4550812 | — | k_off | = | - | s-1 | - |
| CHEMBL5916381 | — | k_off | = | - | s-1 | - |
| CHEMBL4550812 | — | kon | = | - | — | - |
| CHEMBL5902002 | — | kon | = | - | — | - |
| CHEMBL5814595 | — | k_off | = | - | s-1 | - |
| CHEMBL3942843 | — | k_off | = | - | s-1 | - |
| CHEMBL3942843 | — | kon | = | - | — | - |
| CHEMBL5826806 | — | kon | = | - | — | - |
| CHEMBL5826806 | — | k_off | = | - | s-1 | - |
| CHEMBL3944427 | — | k_off | = | - | s-1 | - |
| CHEMBL5964811 | — | kon | = | - | — | - |
| CHEMBL3944427 | — | kon | = | - | — | - |
| CHEMBL5964811 | — | k_off | = | - | s-1 | - |
| CHEMBL6057630 | — | kon | = | - | — | - |
| CHEMBL5749167 | — | k_off | = | - | s-1 | - |
| CHEMBL5749167 | — | kon | = | - | — | - |
| CHEMBL6057630 | — | k_off | = | - | s-1 | - |
| CHEMBL5902002 | — | k_off | = | - | s-1 | - |