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Compound Detail

CHEMBL5750623

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CS(=O)(=O)c1ccc(-c2ccc3ccc4c(c3c2)CC(N)C(c2cc(F)c(F)cc2F)O4)cc1

Basic Information

ChEMBL ID CHEMBL5750623
Phase Preclinical
Structure Type MOL
InChI Key UVQLFHOOLJFJEJ-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

483.5
MW (Da)
5.33
ALogP
4
HBA
1
HBD
69.4
PSA (Ų)
0.40
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H20F3NO3S
MW 483.51
Aromatic Rings 4
Heavy Atoms 34
NP-Likeness -0.28

Activity Summary

IC50 1 meas. best 6.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Dipeptidyl peptidase 4
CHEMBL284
IC50 6.77 6.77 169.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Dipeptidyl peptidase 4 IC50 = 169.0 nM 6.77 Inhibition Activity Assay: Screening Method:Name of method: Activity Evaluation ... -

Data from ChEMBL 36 via Core Engine