Assay Detail
Binding
CHEMBL5735618
Review assay metadata, readout intent, target linkage, and publication context from the same page.
UV-vis cuvette-based assay: UV-vis cuvette-based assay.
27
Total Activities
9
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL2903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.47 | 6.16 |
| kon | 9 | - | - |
| k_off | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3113169 | — | — | 3 | 6.16 |
| CHEMBL3113201 | — | — | 3 | 5.89 |
| CHEMBL3113198 | — | — | 3 | 5.35 |
| CHEMBL3113192 | — | — | 3 | 5.29 |
| CHEMBL3113178 | — | — | 3 | 5.12 |
| CHEMBL3113165 | VLX-1005 | 2.0 | 3 | 5.01 |
| CHEMBL3113166 | — | — | 3 | - |
| CHEMBL3113167 | — | — | 3 | - |
| CHEMBL3113197 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3113169 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL3113201 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3113198 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3113192 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL3113178 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3113165 | VLX-1005 | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL3113165 | VLX-1005 | kon | = | - | — | - |
| CHEMBL3113165 | VLX-1005 | k_off | = | - | s-1 | - |
| CHEMBL3113166 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3113166 | — | kon | = | - | — | - |
| CHEMBL3113166 | — | k_off | = | - | s-1 | - |
| CHEMBL3113167 | — | IC50 | > | 70000.0 | nM | - |
| CHEMBL3113167 | — | kon | = | - | — | - |
| CHEMBL3113167 | — | k_off | = | - | s-1 | - |
| CHEMBL3113169 | — | kon | = | - | — | - |
| CHEMBL3113169 | — | k_off | = | - | s-1 | - |
| CHEMBL3113178 | — | k_off | = | - | s-1 | - |
| CHEMBL3113192 | — | kon | = | - | — | - |
| CHEMBL3113192 | — | k_off | = | - | s-1 | - |
| CHEMBL3113197 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL3113197 | — | kon | = | - | — | - |
| CHEMBL3113197 | — | k_off | = | - | s-1 | - |
| CHEMBL3113198 | — | kon | = | - | — | - |
| CHEMBL3113198 | — | k_off | = | - | s-1 | - |
| CHEMBL3113201 | — | kon | = | - | — | - |
| CHEMBL3113201 | — | k_off | = | - | s-1 | - |
| CHEMBL3113178 | — | kon | = | - | — | - |