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Assay Detail

CHEMBL5735880

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
TBD: TBD
ChEMBL ↗
813
Total Activities
266
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Heterocyclic compounds as immunomodulators
(2020)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 271 5.53 6.12
kon 271 - -
k_off 271 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5771886 — — 3 6.12
CHEMBL5763043 — — 3 6.12
CHEMBL5842891 — — 3 6.12
CHEMBL5752223 — — 3 5.52
CHEMBL5812359 — — 3 5.52
CHEMBL5411364 — — 3 5.52
CHEMBL5401026 — — 3 5.52
CHEMBL5946349 — — 3 5.52
CHEMBL5995271 — — 3 5.52
CHEMBL6059360 — — 3 5.52
CHEMBL6005695 — — 3 5.52
CHEMBL5850451 — — 3 5.52
CHEMBL5842759 — — 3 5.52
CHEMBL5990924 — — 3 5.52
CHEMBL5810816 — — 3 5.52
CHEMBL6019153 — — 3 5.52
CHEMBL6054745 — — 3 5.52
CHEMBL5906499 — — 3 5.52
CHEMBL6014522 — — 3 5.52
CHEMBL5992184 — — 3 5.52
CHEMBL6034541 — — 3 5.52
CHEMBL5892338 — — 3 5.52
CHEMBL5856438 — — 3 5.52
CHEMBL6035158 — — 3 5.52
CHEMBL5909892 — — 3 5.52
CHEMBL5924525 — — 3 5.52
CHEMBL5972829 — — 3 5.52
CHEMBL5990459 — — 3 5.52
CHEMBL5899201 — — 3 5.52
CHEMBL4860688 — — 3 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5771886 — IC50 = 750.0 nM 6.12
CHEMBL5842891 — IC50 = 750.0 nM 6.12
CHEMBL5763043 — IC50 = 750.0 nM 6.12
CHEMBL5885229 — IC50 = 3000.0 nM 5.52
CHEMBL5925854 — IC50 = 3000.0 nM 5.52
CHEMBL5890989 — IC50 = 3000.0 nM 5.52
CHEMBL5987436 — IC50 = 3000.0 nM 5.52
CHEMBL5761439 — IC50 = 3000.0 nM 5.52
CHEMBL6061057 — IC50 = 3000.0 nM 5.52
CHEMBL5801288 — IC50 = 3000.0 nM 5.52
CHEMBL5921710 — IC50 = 3000.0 nM 5.52
CHEMBL5862236 — IC50 = 3000.0 nM 5.52
CHEMBL5972065 — IC50 = 3000.0 nM 5.52
CHEMBL5870632 — IC50 = 3000.0 nM 5.52
CHEMBL5855328 — IC50 = 3000.0 nM 5.52
CHEMBL5845243 — IC50 = 3000.0 nM 5.52
CHEMBL5877583 — IC50 = 3000.0 nM 5.52
CHEMBL6004702 — IC50 = 3000.0 nM 5.52
CHEMBL5877583 — IC50 = 3000.0 nM 5.52
CHEMBL5929565 — IC50 = 3000.0 nM 5.52
CHEMBL5871181 — IC50 = 3000.0 nM 5.52
CHEMBL5834416 — IC50 = 3000.0 nM 5.52
CHEMBL5886751 — IC50 = 3000.0 nM 5.52
CHEMBL5993340 — IC50 = 3000.0 nM 5.52
CHEMBL5944049 — IC50 = 3000.0 nM 5.52
CHEMBL5982242 — IC50 = 3000.0 nM 5.52
CHEMBL6055287 — IC50 = 3000.0 nM 5.52
CHEMBL5785697 — IC50 = 3000.0 nM 5.52
CHEMBL5781082 — IC50 = 3000.0 nM 5.52
CHEMBL6039244 — IC50 = 3000.0 nM 5.52
CHEMBL5885000 — IC50 = 3000.0 nM 5.52
CHEMBL5792357 — IC50 = 3000.0 nM 5.52
CHEMBL5854366 — IC50 = 3000.0 nM 5.52
CHEMBL5803445 — IC50 = 3000.0 nM 5.52
CHEMBL5775365 — IC50 = 3000.0 nM 5.52
CHEMBL5898313 — IC50 = 3000.0 nM 5.52
CHEMBL6025156 — IC50 = 3000.0 nM 5.52
CHEMBL5989513 — IC50 = 3000.0 nM 5.52
CHEMBL6039545 — IC50 = 3000.0 nM 5.52
CHEMBL5771938 — IC50 = 3000.0 nM 5.52
CHEMBL5987957 — IC50 = 3000.0 nM 5.52
CHEMBL5794015 — IC50 = 3000.0 nM 5.52
CHEMBL5776707 — IC50 = 3000.0 nM 5.52
CHEMBL6000911 — IC50 = 3000.0 nM 5.52
CHEMBL5839262 — IC50 = 3000.0 nM 5.52
CHEMBL5993550 — IC50 = 3000.0 nM 5.52
CHEMBL5865062 — IC50 = 3000.0 nM 5.52
CHEMBL5807117 — IC50 = 3000.0 nM 5.52
CHEMBL5950495 — IC50 = 3000.0 nM 5.52
CHEMBL5947291 — IC50 = 3000.0 nM 5.52