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Assay Detail

CHEMBL5735899

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
TBD: TBD
ChEMBL ↗
2811
Total Activities
788
Compounds Tested
3
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase BTK (CHEMBL5251) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of Bruton's tyrosine kinase and method of their use
(2020)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 937 6.87 8.40
kon 937 - -
k_off 937 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5775653 — — 6 8.40
CHEMBL5774785 — — 12 8.30
CHEMBL5874983 — — 3 8.30
CHEMBL5957494 — — 6 8.20
CHEMBL5209441 — — 6 8.20
CHEMBL5936852 — — 3 8.20
CHEMBL5877855 — — 3 8.20
CHEMBL5963061 — — 3 8.20
CHEMBL5171216 — — 3 8.20
CHEMBL5923752 — — 3 8.20
CHEMBL5208792 — — 3 8.20
CHEMBL5812313 — — 3 8.10
CHEMBL5171115 — — 6 8.10
CHEMBL5875002 — — 3 8.10
CHEMBL5741340 — — 3 8.10
CHEMBL5861043 — — 3 8.10
CHEMBL5777190 — — 3 8.10
CHEMBL5188975 — — 9 8.10
CHEMBL5197092 — — 6 8.10
CHEMBL5181715 — — 9 8.10
CHEMBL5826019 — — 3 8.10
CHEMBL5858516 — — 3 8.10
CHEMBL5821687 — — 3 8.10
CHEMBL5807681 — — 6 8.10
CHEMBL4853403 — — 15 8.10
CHEMBL4851021 — — 12 8.10
CHEMBL5747624 — — 6 8.00
CHEMBL5942476 — — 6 8.00
CHEMBL5763998 — — 9 8.00
CHEMBL5879884 — — 3 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5775653 — IC50 = 3.98 nM 8.40
CHEMBL5774785 — IC50 = 5.01 nM 8.30
CHEMBL5874983 — IC50 = 5.01 nM 8.30
CHEMBL5208792 — IC50 = 6.31 nM 8.20
CHEMBL5774785 — IC50 = 6.31 nM 8.20
CHEMBL5963061 — IC50 = 6.31 nM 8.20
CHEMBL5877855 — IC50 = 6.31 nM 8.20
CHEMBL5936852 — IC50 = 6.31 nM 8.20
CHEMBL5923752 — IC50 = 6.31 nM 8.20
CHEMBL5171216 — IC50 = 6.31 nM 8.20
CHEMBL5957494 — IC50 = 6.31 nM 8.20
CHEMBL5775653 — IC50 = 6.31 nM 8.20
CHEMBL5209441 — IC50 = 6.31 nM 8.20
CHEMBL5812313 — IC50 = 7.94 nM 8.10
CHEMBL5858516 — IC50 = 7.94 nM 8.10
CHEMBL5821687 — IC50 = 7.94 nM 8.10
CHEMBL5188975 — IC50 = 7.94 nM 8.10
CHEMBL5774785 — IC50 = 7.94 nM 8.10
CHEMBL4853403 — IC50 = 7.94 nM 8.10
CHEMBL5807681 — IC50 = 7.94 nM 8.10
CHEMBL5777190 — IC50 = 7.94 nM 8.10
CHEMBL5171115 — IC50 = 7.94 nM 8.10
CHEMBL4851021 — IC50 = 7.94 nM 8.10
CHEMBL5181715 — IC50 = 7.94 nM 8.10
CHEMBL5741340 — IC50 = 7.94 nM 8.10
CHEMBL5197092 — IC50 = 7.94 nM 8.10
CHEMBL5861043 — IC50 = 7.94 nM 8.10
CHEMBL5826019 — IC50 = 7.94 nM 8.10
CHEMBL5875002 — IC50 = 7.94 nM 8.10
CHEMBL5879884 — IC50 = 10.0 nM 8.00
CHEMBL5948627 — IC50 = 10.0 nM 8.00
CHEMBL5745475 — IC50 = 10.0 nM 8.00
CHEMBL6024079 — IC50 = 10.0 nM 8.00
CHEMBL5839419 — IC50 = 10.0 nM 8.00
CHEMBL5777162 — IC50 = 10.0 nM 8.00
CHEMBL6057149 — IC50 = 10.0 nM 8.00
CHEMBL5960620 — IC50 = 10.0 nM 8.00
CHEMBL5942476 — IC50 = 10.0 nM 8.00
CHEMBL5763207 — IC50 = 10.0 nM 8.00
CHEMBL5745368 — IC50 = 10.0 nM 8.00
CHEMBL5881717 — IC50 = 10.0 nM 8.00
CHEMBL5763998 — IC50 = 10.0 nM 8.00
CHEMBL5744684 — IC50 = 10.0 nM 8.00
CHEMBL5856608 — IC50 = 10.0 nM 8.00
CHEMBL6054418 — IC50 = 10.0 nM 8.00
CHEMBL5747624 — IC50 = 10.0 nM 8.00
CHEMBL5934435 — IC50 = 10.0 nM 8.00
CHEMBL6035526 — IC50 = 12.6 nM 7.90
CHEMBL5990816 — IC50 = 12.6 nM 7.90
CHEMBL5777981 — IC50 = 12.6 nM 7.90