Assay Detail
Binding
CHEMBL5736244
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In Vitro Assay: Assays were done by measuring the transfer of tritium from 15(S)-[15-3H] PGE2 to glutamate (at 1 μM PGE2 substrate), or by direct fluorescence monitoring of NADH generation by 15-PGDH (done at 20 μM PGE2 substrate.
282
Total Activities
91
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
15-hydroxyprostaglandin dehydrogenase [NAD(+)] (CHEMBL1293255) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Compositions and methods of modulating short-chain dehydrogenase activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 94 | 8.01 | 9.01 |
| kon | 94 | - | - |
| k_off | 94 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072253 | — | — | 3 | 9.01 |
| CHEMBL4060121 | — | — | 3 | 8.94 |
| CHEMBL5794676 | — | — | 9 | 8.89 |
| CHEMBL4091103 | — | — | 3 | 8.87 |
| CHEMBL4097930 | — | — | 3 | 8.86 |
| CHEMBL4070824 | — | — | 3 | 8.86 |
| CHEMBL5763449 | — | — | 3 | 8.85 |
| CHEMBL5902819 | — | — | 3 | 8.85 |
| CHEMBL4071206 | — | — | 3 | 8.74 |
| CHEMBL4076946 | — | — | 3 | 8.70 |
| CHEMBL4087830 | — | — | 3 | 8.69 |
| CHEMBL4090222 | — | — | 3 | 8.68 |
| CHEMBL4092806 | — | — | 3 | 8.67 |
| CHEMBL4059682 | — | — | 3 | 8.64 |
| CHEMBL4087985 | — | — | 3 | 8.62 |
| CHEMBL4061483 | — | — | 3 | 8.60 |
| CHEMBL5947102 | — | — | 3 | 8.60 |
| CHEMBL4073304 | — | — | 3 | 8.60 |
| CHEMBL5867179 | — | — | 3 | 8.60 |
| CHEMBL4092188 | — | — | 3 | 8.59 |
| CHEMBL4065965 | — | — | 3 | 8.58 |
| CHEMBL4072938 | — | — | 3 | 8.58 |
| CHEMBL5908068 | — | — | 3 | 8.57 |
| CHEMBL6009480 | — | — | 3 | 8.54 |
| CHEMBL5868063 | — | — | 3 | 8.54 |
| CHEMBL4076321 | — | — | 3 | 8.52 |
| CHEMBL4099821 | — | — | 3 | 8.50 |
| CHEMBL4074740 | — | — | 3 | 8.48 |
| CHEMBL4070888 | — | — | 3 | 8.47 |
| CHEMBL4093974 | — | — | 3 | 8.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072253 | — | IC50 | = | 0.97 | nM | 9.01 |
| CHEMBL4060121 | — | IC50 | = | 1.14 | nM | 8.94 |
| CHEMBL5794676 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL4091103 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL4097930 | — | IC50 | = | 1.37 | nM | 8.86 |
| CHEMBL4070824 | — | IC50 | = | 1.37 | nM | 8.86 |
| CHEMBL5763449 | — | IC50 | = | 1.43 | nM | 8.85 |
| CHEMBL5902819 | — | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL4071206 | — | IC50 | = | 1.83 | nM | 8.74 |
| CHEMBL4076946 | — | IC50 | = | 1.99 | nM | 8.70 |
| CHEMBL4087830 | — | IC50 | = | 2.05 | nM | 8.69 |
| CHEMBL4090222 | — | IC50 | = | 2.09 | nM | 8.68 |
| CHEMBL4092806 | — | IC50 | = | 2.13 | nM | 8.67 |
| CHEMBL4059682 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4087985 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL5867179 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4073304 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4061483 | — | IC50 | = | 2.53 | nM | 8.60 |
| CHEMBL5947102 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL5794676 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4092188 | — | IC50 | = | 2.56 | nM | 8.59 |
| CHEMBL4072938 | — | IC50 | = | 2.61 | nM | 8.58 |
| CHEMBL4065965 | — | IC50 | = | 2.65 | nM | 8.58 |
| CHEMBL5908068 | — | IC50 | = | 2.71 | nM | 8.57 |
| CHEMBL6009480 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL5868063 | — | IC50 | = | 2.86 | nM | 8.54 |
| CHEMBL4076321 | — | IC50 | = | 2.99 | nM | 8.52 |
| CHEMBL4099821 | — | IC50 | = | 3.16 | nM | 8.50 |
| CHEMBL4074740 | — | IC50 | = | 3.33 | nM | 8.48 |
| CHEMBL4070888 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4093974 | — | IC50 | = | 3.48 | nM | 8.46 |
| CHEMBL4095639 | — | IC50 | = | 3.45 | nM | 8.46 |
| CHEMBL5844725 | — | IC50 | = | 3.53 | nM | 8.45 |
| CHEMBL5761918 | — | IC50 | = | 3.73 | nM | 8.43 |
| CHEMBL4077682 | — | IC50 | = | 3.71 | nM | 8.43 |
| CHEMBL5866860 | — | IC50 | = | 3.99 | nM | 8.40 |
| CHEMBL4082378 | — | IC50 | = | 4.01 | nM | 8.40 |
| CHEMBL4060870 | — | IC50 | = | 3.97 | nM | 8.40 |
| CHEMBL4065035 | — | IC50 | = | 4.06 | nM | 8.39 |
| CHEMBL5875224 | — | IC50 | = | 4.18 | nM | 8.38 |
| CHEMBL4064717 | — | IC50 | = | 4.29 | nM | 8.37 |
| CHEMBL5928952 | — | IC50 | = | 4.36 | nM | 8.36 |
| CHEMBL4066687 | — | IC50 | = | 4.87 | nM | 8.31 |
| CHEMBL4101333 | — | IC50 | = | 5.27 | nM | 8.28 |
| CHEMBL5840661 | — | IC50 | = | 5.55 | nM | 8.26 |
| CHEMBL5823316 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL4099492 | — | IC50 | = | 5.87 | nM | 8.23 |
| CHEMBL4081420 | — | IC50 | = | 6.14 | nM | 8.21 |
| CHEMBL4074636 | — | IC50 | = | 6.67 | nM | 8.18 |
| CHEMBL6032546 | — | IC50 | = | 7.62 | nM | 8.12 |