Compound Detail
CHEMBL5867179
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C=CCNC(=O)c1cccc(-c2cc(-c3nccs3)nc3sc([S+]([O-])CCCC)c(N)c23)c1
Basic Information
| ChEMBL ID | CHEMBL5867179 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OHAHLCPUAQSXCM-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
496.7
MW (Da)
5.49
ALogP
7
HBA
2
HBD
104.0
PSA (Ų)
0.24
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] CHEMBL1293255 | IC50 | 8.6 | 8.6 | 2.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | IC50 | = | 2.5 | nM | 8.6 | In Vitro Assay: Each compound for inhibiting enzymatic activity of recombinant 1... | - |
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | IC50 | = | 2.5 | nM | 8.6 | In Vitro Assay: Assays were done by measuring the transfer of tritium from 15(S)... | - |
Data from ChEMBL 36 via Core Engine